Biology ebook

The Lehnninger Biochemsitry

2009-04-19T13:00:00.001-07:00

The Lehnninger text has a long history, but given that biochemical knowledge doubles every 5 years or so, it matters what a text offers now, not in the past. The writing style is simple, direct, engaging, not too easy but neither too esoteric. The principles (as the title suggests) and the unity in diversity are emphasized, so that the student understands biochemical principles not merely facts, acronyms, pathways. The graphics are very professional. They are comparable to any review article in hot journals such as Nature, Science, Cell, etc. The rendering of protein surfaces, and the different angles through which a structure is seen is outstanding (a good example is the section on the ribosome). The structures have been rendered from the PDB (protein data bank) coordinates.

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Microbiology, 5th by Lannsing M. Preescott

2009-04-19T12:58:00.002-07:00

Prescot, Harlley and Kleein's 5th edition provides a balanced, comprehensive introduction to all major areas of microbiology. Because of this balance, Microbiology, 5/e is appropriate for students preparing for careers in medicine, dentistry, nursing, and allied health, as well as research, teaching, and industry. Biology and chemistry are prerequisites. The Fifth Edition has been updated extensively to reflect the latest discoveries in the field.This book is nicely done, all together. The flow of information is well organized, with great cross-references and detailed graphs and pictures to help understand important concepts. Also, several appendices, a glossary, serve as helpful resources. The material is presented in a tasteful manner, not reducing the book to a mere picture book. This book, written for undergraduate and graduate students, gives serious information and is very detailed.
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Immunology

2009-04-19T12:58:00.001-07:00

It's easy to read, easy to understand, very good graphics; Kuby is a very friendly book for new students, and for refreshing many concepts if you are very busy (and I bet you are!). I love it. But if you have more time available for reading, I would recommend Fundamental Immunology (Paul) and Cellular and Molecular Immunology by Abbas.
And try to keep up-to-date with new material on scientific magazines. See, in research you don't depend on books, that's only at the beginning or if you have to refresh some concepts. Once you have your knowledge, you will be reading papers on scientific magazines and less books. Many times, the concepts you have learned on books can change very fast. Science is a dynamic field, always changing.

Genes 8

2009-04-19T12:56:00.001-07:00

Genes 8 changed the approach to begin with the sequence of the human and other genomes and starts with complete coverage of recent advances in genomics. The coverage of genomics is then integrated throughout the text.Two decades ago Benjamin Lewin’s Genes revolutionized the way we think about and teach molecular biology and molecular genetics. His approach unified the discipline by providing an integrated account of the structure and function of genes in both prokaryotes and eukaryotes.
Setting a standard for currency, Genes continually embraces emerging trends in this field, such as introducing the molecular aspect of the gene before the traditional analysis of formal genetics. Genes VIII continues to innovate; expanding the early discussion of the genome and integrating new information on gene sequencing throughout the text.

Developing Bioinformatics Computer Skills

2009-03-06T06:56:00.001-08:00

Bioinformatics--the application of computational and analytical methods to biological problems--is a rapidly evolving scientific discipline. As a result of advances in gene sequencing, biological databases are growing exponentially. It's impossible for even the most zealous researcher to stay on top of necessary information in the field without the aid of computer-based tools. Written in a clear, engaging style, Developing Bioinformatics Computer Skills is for scientists and students who are learning computational approaches to biology, as well as for experienced biology researchers who are just starting to use computers to handle their data. The book covers the Unix file system, building tools and databases for bioinformatics, computational approaches to biological problems, an introduction to Perl for bioinformatics,data mining, data visualization, and tips for tailoring existing data analysis software to individual research needs. Developing Bioinformatics Computer Skills will help biologists develop a structured approach to biological data as well as the tools they'll need to analyze it.
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Modern Industrial Microbiology and Biotechnology

2009-03-06T06:54:00.001-08:00

This book is directed towards undergraduates and beginning graduate students in microbiology, food science and chemical engineering. Those studying pharmacy, biochemistry and general biology will find it of interest. The section on waste disposal will be of interest to civil engineering and public health students and practitioners. For the benefit of those students who may be unfamiliar with the basic biological assumptions underlying industrial microbiology, such as students of chemical and civil engineering, elements of biology and microbiology are introduced. The new elements which have necessitated the shift in paradigm in industrial microbiology such as bioinformatics, genomics, proteomics, site-directed mutation, metabolic engineering, the human genome project and others are also introduced and their relevance to industrial microbiology and biotechnology indicated. As many references as space will permit are included. The various applicationsof industrial microbiology are covered broadly, and the chapters are grouped to reflect these applications. The emphasis throughout, however, is on the physiological, biochemical principles, and where possible, the genomic principles behind these applications.
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Biotechnology Unzipped: Promises And Realities

2009-03-06T06:50:00.000-08:00

BIOTECHNOLOGY UNZIPPED is the most compelling evaluation of biotechnology I have read since Harsanyi & Hutton's GENETIC PROPHECY of almost 20 years ago. What makes this book so insightful is the "tradeoffs" perspective that Grace brings to the subject. In every instance where a particular technique is either in development or on the market, the possibilities for selective breeding, or genetic engineering, or composite materials, all hold both a promise and a peril. Grace, who has a Ph.D. in Zoology and considerable experience as a science writer, attempts to provide enough critical information in each case so that the reader will get a sense of what considerations are involved in any particular "biotechnology solution". What we learn about biotechnology from him is that every biotechnology decision has the following characteristics: * Costs and revenues (developments cost $millions, so the goal is profits) * Winners and losers (the rich could get lucky, the poor and vulnerable may not) * Benefits and detriments (solutions generate unintended & unwanted consequences) * Enthusiasts and detractors (arguments arise on all sides of biotechnology issues) The reason that the public is so ambivalent about biotechnology is that its supporters have been so inept at making their case. Biotechnology advocates seem to think that their's is just a problem of an "uninformed public" whom they can re- assure because they have "the facts". They obviously don't appreciate the most important principle of new-age , "They don't care how much you know until they know how much you care". What Grace shows is that the public does have cause to be concerned. There are no simple problems, no silver bullets, and no final solutions, even if biotechnology boosters pretend there are. If biotechnology advocates become willing to address these concerns, AND learn to manage the expectations of their stakeholders, then they can begin to earn the respect that will otherwise continue to elude them. Grace's book helps clarify all of this. . Grace's book helps clarify all of this.
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Molecular Biology of Protein Folding

2009-03-04T22:50:00.000-08:00

Author(s): P. Michael Conn

Series: Progress in Nucleic Acid Research and Molecular Biology, vol.83

Publisher: Academic Press

ISBN: 0123745942

Publication: 2008

Pages: 304

Description: The importance of protein folding has been recognized for many years. It is the underlying etiology in a large number of human diseases and it appears to be a novel method for cellular regulation of the expression of newly translated proteins. These volumes (Parts A & B) address this important topic. As a volume in Progress in Nucleic Acid Research and Molecular Biology, this book provides the latest information on the expanding research being conducted on protein folding. Illustrates how ubiquitin domain proteins are an ideal model system for experimental and computational studies of protein folding. Discusses structural wrapping and its importance in the contexts of network centrality, molecular disease, drug discovery and molecular theranostic engineering. Chapters written by international authors in engineering, biochemistry, physics, and computer science.

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Basic Endocrinology: An Interactive Approach

2009-03-04T22:44:00.000-08:00

Title: Basic Endocrinology: An Interactive Approach

Author(s): J. Matthew, M.D. Neal

Series: Advances in Pathology, Microscopy, and Molecular Morphology

Publisher: Blackwell Publishers

ISBN: 0632044292

Publication: 2000

Pages: 282

Description: Indiana Univ., Muncie. Introductory textbook for medical students and residents in a problem-based, self-assessment format. Presented as "frequently asked questions," and asks the student "why" rather than restating lecture material. One-third of the book consists of review questions accompanied by diagrams and photographs.

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Proteins: Structure and Function

2009-02-14T13:18:00.001-08:00

Proteins: Structure and Function is a comprehensive introduction to the study of proteins and their importance to modern biochemistry. Each chapter addresses the structure and function of proteins with a definitive theme designed to enhance student understanding. Opening with a brief historical overview of the subject the book moves on to discuss the ‘building blocks’ of proteins and their respective chemical and physical properties. Later chapters explore experimental and computational methods of comparing proteins, methods of protein purification and protein folding and stability. The latest developments in the field are included and key concepts introduced in a user-friendly way to ensure that students are able to grasp the essentials before moving on to more advanced study and analysis of proteins.
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Transcription (Cell and Biomolecular Sciences)

2009-02-14T13:17:00.000-08:00

transcription has moved forward at a furious pace over recent years, and an understanding of the processes involved in gene regulation and expression has become an essential element in biochemistry, genome biology, molecular biology and molecular genetics. In this timely book, the authors present an accessible, yet comprehensive, coverage suitable for students at a senior undergraduate level, and for postgraduates needing an overview of the current state of play. Transcription shows examples of transcription systems for eukaryotes and prokaryotes, indicates methods for studying transcription, and surveys the whole topic of transcription from many perspectives..

Wine Chemistry and Biochemistry

2009-02-14T13:16:00.000-08:00

The aim of this book is to describe chemical and biochemical aspects of winemaking that are currently being researched. The authors have selected the very best experts for each of the areas. The first part of the book summarizes the most important aspects of winemaking technology and microbiology. The second most extensive part deals with the different groups of compounds, how these are modified during the various steps of the production process, and how they affect the wine quality, sensorial aspects, and physiological activity, etc. The third section describes undesirable alterations of wines, including those affecting quality and food safety. Finally, the treatment of data will be considered, an aspect which has not yet been tackled in any other book on enology. In this chapter, the authors not only explain the tools available for analytical data processing, but also indicate the most appropriate treatment to apply, depending on the information required, illustrating with examples throughout the chapter from enological literature.

Mitochondria, 2nd edition

2009-02-14T13:15:00.000-08:00

This book is the eagerly awaited second edition of the best-selling Mitochondria, a book widely acknowledged as the first modern, truly comprehensive authored work on the important, scientifically fundamental topic of the cellular organelles known as mitochondria.

This new edition brings readers completely up to date on the many significant findings that have occurred in the eight years since the book was first published. As in that seminal first edition, the second edition tackles the biochemistry, genetics, and pathology of mitochondria in different organisms. The new edition provides thorough updates of all literature concerning this vital organelle, its functions, ongoing research surrounding it, and its importance vis-à-vis a broad range of issues in cellular and molecular biology. The book includes detailed descriptions of current and developing technologies around mitochondrial research and discovery, and highlights subjects that are growing, such as the use of proteomics..

Drug-Drug Interactions in Pharmaceutical Development

2009-02-06T14:57:00.000-08:00

Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market. The book covers both clinical and nonclinical aspects for understanding drug-drug interactions as well as in vitro and in vivo studies for use in studying interactions at the drug discovery stage.

Gene cloning

2009-02-06T14:54:00.001-08:00

Description: Cloning genes has become such a routine part of molecular biology, and the approaches to it so many and diverse, undergraduates can easily be overwhelmed. Gene Cloning is designed to give the undergraduate a broad overview of the subject, guiding the student through the basic elements involved and their utility, and further through the interpretation of results and datasets. Having understood the basic processes, the reader is introduced to some of the most common uses of gene cloning, from applications with more research-oriented goals to practical applications in biotechnology in medicine. Clearly presented in two-colour text, Gene Cloning is essential reading for undergraduates in the molecular life sciences.

Gene Regulation

2009-02-06T14:53:00.000-08:00

Description: Gene regulation is an essential process in the development and maintenance of a healthy body, and as such is a central focus in both basic science and medical research. Gene Regulation, Fifth Edition, provides the student with a clear, up-to-date description of gene regulation in eukaryotes, distilling the vast and complex primary literature into a concise overview. For this fifth edition, in addition to extensive updating of existing material, sections on large-scale methodologies have been expanded, and a new section included on regulation by small interfering RNAs. More detail has been added on the role of multi-protein complexes in transcriptional activation and the discussion of the regulation of factor activity by specific modifications to include acetylation and ubiquitination as well as phosphorylation. The final chapter on gene regulation and human disease now includes additional novel examples, such as RNA edition in motor neurone disease, role of the transcriptional co-activator CBP in Alzheimer's disease and PML-RAR involvement in acute promyelocytic leukemia.

Boost Your Interview IQ

2009-02-06T14:50:00.000-08:00

How to become an interview genius and land the job of your dreams

If a job interview is an oral exam in which give the right answers to a set of questions in order to get hired, then this is the ultimate guide to acing the exam. Written by The Interview Coach at Monster.com, Boost Your Interview IQ offers an enjoyable, interactive way to prepare for and succeed at any job interview.

Combining the features of a step-by-step guide and a skill-building workbook, it:

* Shows job seekers how to craft job-winning answers to the 50 key questions interviewers ask
* Features an Interview IQ Test, interview skill-building exercises, and other interview aptitude boosting tools
* Teaches candidates how to shape their experiences into stories that showcase their skills, knowledge, and personalities
* Offers proven techniques for acing the behavioral interview--the popular new wave interviewing strategy How to become an interview genius and land the job of your dreams

Nature Reviews Molecular Cell Biology [Volume 8 Jan (2007) - Sep (2007)]

2009-02-03T08:28:00.001-08:00

Molecular cell biology is a marriage
of two distinct, yet complementary, disciplines. In its traditional sense, the term 'molecular biology' refers to study of the macromolecules essential to life — nucleic acids and proteins. The field of cell biology is a natural extension of this, integrating what we know at the molecular level into an understanding of processes and interactions at the cellular level. Only by combining both fields can we paint a broad picture of essential biological processes such as how cells divide, grow, communicate and die.

Nature Reviews Molecular Cell Biology takes readers on a journey from the nucleus of a cell to its boundaries and beyond. It features Reviews and Perspectives articles on a broad range of topics, and highlights important primary papers and technological progress

Soil Microbiology, Ecology and Biochemistry

2009-02-03T08:26:00.000-08:00

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Now in its third edition, this classic textbook includes basic concepts and applications in agriculture, forestry, environmental science, and a new section entirely devoted to ecology. This revised and updated edition guides students through biochemical and microbial processes in soils and introduces them to microbial processes in water and sediments. Soil Microbiology, Ecology, and Biochemistry serves as an invaluable resource
for students in biogeochemistry, soil microbiology, soil ecology, sustainable agriculture, and environmental amelioration.

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Animal Biotechnology: Science-Based Concerns

2009-02-03T08:23:00.000-08:00

Genetic-based animal biotechnology has produced new food and pharmaceutical products and promises many more advances to benefit humankind. These exciting prospects are accompanied by considerable unease, however, about matters such as safety and ethics. This book identifies science-based and policy-related concerns about animal biotechnologyï¿½key issues that must be resolved before the new breakthroughs can reach their potential. The book includes a short history of the field and provides understandable definitions of terms like cloning. Looking at technologies on the near horizon, the authors discuss what we know and what we fear about their effectsï¿½the inadvertent release of dangerous microorganisms, the safety of products derived from biotechnology, the impact of genetically engineered animals on their environment. In addition to these concerns, the book explores animal welfare concerns, and our societal and institutional capacity to manage and regulate the technology and its products. This accessible volume will be important to everyone interested in the implications of the use of animal biotechnology.t

Science Magazine ~ Vol 323 16th January 2009

2009-01-21T02:24:00.000-08:00

New Sciet ntist magaz ine - 29th November 2008

2009-01-21T02:22:00.000-08:00

RNA Technologies in Cardiovascular Medicine and Research

2009-01-21T02:21:00.000-08:00

In this book the authors review the field and explore the potential role of RNAi and other RNA technologies in cardiovascular medicine and research. They highlight the impressive recent progress but also the hurdles that still must be overcome before this promising technology is finally ready for translation and clinical use.t

Functional Proteomics

2009-01-21T02:18:00.000-08:00

As the emerging field of proteomics continues to expand at an extremely rapid rate, the relative quantification of proteins, targeted by their function, becomes its greatest challenge. Complex analytical strategies have been designed that allow comparative analysis of large proteomes, as well as in depth detection of the core proteome or the interaction of a given protein of interest. In Functional Proteomics: Methods and Protocols, expert researchers describe the latest protocols being developed to address the problems encountered in high-throughput proteomics projects, with emphasis on the factors governing the technical choices for given applications. The case studies within the volume focus on the following three crucial aspects of the experimental design: 1) the strategy used for the selection, purification and preparation of the sample to be analyzed by mass spectrometry, 2) the type of mass spectrometer used and the type of data to be obtained from it, and 3) the method used for the interpretation of the mass spectrometry data and the used for the identification of the proteins in the different types of sequence data banks available. As a part of the highly successful Methods in Molecular Biology™ series, the chapters compile step-by-step, readily reproducible laboratory protocols, lists of the necessary materials and reagent

s, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Functional Proteomics: Methods and Protocols is an ideal resource for all scientists pursuing this developing field and its multitudinous data.

The Way of the Cell: Molecules, Organisms, and the Order of Life

2009-01-18T21:14:00.001-08:00

What is life? Fifty years after physicist Erwin Schrodinger posed this question in his celebrated and inspiring book, the answer remains elusive. In The Way of the Cell, one of the world's most respected microbiologists draws on his wide knowledge of contemporary science to provide fresh insight into this intriguing and all-important question.
What is the relationship of living things to the inanimate realm of chemistry and physics? How do lifeless but special chemicals come together to form those intricate dynamic ensembles that we recognize as life? To shed light on these questions, Franklin Harold focuses here on microorganisms--in particular, the supremely well-researc

hed bacterium E. coli --because the cell is the simplest level of organization that manifests all the features of the phenomenon of life. Harold shows that as simple as they appear when compared to ourselves, every cell displays a dynamic pattern in space and time, orders of magnitude richer than its elements.

Proteomics for Biological Discovery

2009-01-18T21:11:00.000-08:00

Written by recognized experts in the study of proteins, Proteomics for Biological Discovery begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research.

Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applications
Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future indu
stry and basic science applications
Discusses higher level integrative aspects, including technica l challenges and applications for drug discovery
Accessible to the novice while providing experienced investigators essential information

Vitamins: Their Role in the Human Body

2009-01-18T21:10:00.000-08:00

|Vitamins: Their Role in the Human Body is a single-source reference and textbook that assimilates the latest knowledge about vitamins' biological properties with regard to human nutrition. Introductory chapters cover historical and nutritional aspects of vitamins, detailed aspects of physiology and functional anatomy, biochemistry, immunology, the regulation of protein synthesis by nuclear hormone receptors, and much more. The subsequent thirteen chapters scrutinize each specific vitamin in turn. A glossary, bibliography, and index round out this expert resource intended especially for nutritionists, biochemists, physiologists, physicians, food scientists, food technologists, and other health professionals whether in the fields of research, teaching, or study

. An in-depth overview of vitamins, that does not shy from advanced scientific de

tail but is packed with tools to help the lay reader understand exactly what vitamins are and what they do. Highly recommended especially for health and science student and library collections..

Plant Hormone Signaling

2009-01-18T21:07:00.000-08:00

| Plant growth is regulated by developmental programmes that can be modified by environmental cues acting through endogenous signaling molecules including plant hormones.This volume provides an overview of the biosynthesis, catabolism, perception and signal transduc tion of the individual hormone classes, followed by chapt ers on hormone distribution and transport, and the roles of hormone signaling in specific developmental processes. Particular attention is paid to the regulation of hormone signaling by environmental and developmental cues , sites of hormone m

etabolism and action, and interactions between h ormone signalin g pathways . The bo ok is directed at researchers and pro fessionals in plant biochemistry and molecular biology.

Principles of Cancer Genetics

2009-01-16T14:56:00.000-08:00

Cancer genetics is a field of daunting breadth and depth. The literature describes hundreds of genes and genetic alterations that are variably associated with again as many disease states and risk factors. Integrating these disparate pieces of highly specialized information is challenging for the professional scientist and student alike. Prinicples of Cancer Genetics consolidates the main concepts of the cancer gene theory, and provides a framework for understanding the genetic basis of cancer. Focused on the most highly representative genes that underlie the most common cancers, Principles of Cancer Genetics is aimed at advanced undergraduates who have completed introductory courses in genetics, biology and biochemistry, medical students, and house medical house staff preparing for board examinations. Primary attention is devoted to the origins of cancer genes and the application of evolutionary theory to explain why the cell clones that harbor cancer genes tend to expand. The many points of controversy in cancer research are avoided, in favor of firmly established concepts. This book does not delve into tumor pathobiology beyond what is required to understand the role of genetic alterations in neoplastic growth. For students with a general interest in cancer, this book will provide a highly accessible overview. For students contemplating future study in the fields of oncology or cancer research, this book will be useful as a primer.
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An Introduction to Genetic Engineering

2009-01-16T14:55:00.000-08:00

Des Nicholl presents a new, fully revised, and expanded edition of his popular undergraduate-level textbook. The book retains many of the features of the original edition and still offers a concise technical introduction to the subject of genetic engineering. It is divided into three main sections: basic molecular biology, methods of gene manipulation, and modern applications of genetic engineering. Applications covered in the book include genomics, protein engineering, gene therapy, cloning, transgenic animals and plants, and bioethics. An Introduction to Genetic Engineering is essential reading for undergraduate students of biotechnology, genetics, molecular biology, and biochemistry..
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Introduction to Bioinformatics: A Theoretical and Practical Approach

2009-01-16T14:53:00.000-08:00

A comprehensible introduction to the key biological, mathematical, statistical, and computer concepts and tools behind bioinformatics. For physical scientists, the book provides a sound biological framework for understanding the questions a life scientist would ask in the context of currently available computational tools. For life scientists, a complete discussion of the UNIX operating system offers biologists graphical-user-interface comfort in a command-line environment, plus an understanding of the installation and management of UNIX-based software tools. In the applications sections the book provides a common meeting ground for life and physical scientists. Here they will find examples of the management and analysis of DNA sequencing projects, the modeling of DNA as a statistical series of patterns, various methods of pattern discovery, protein visualization, and the use of multiple sequence alignment to infer both functional and structural biological relationships. An accompanying CD contains several full and limited trial-versions of the programs discussed in the text, as well as a complete set of illustrations from each chapter suitable for lectures and presentations..
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Biology at the Single Molecule Level

2009-01-16T14:49:00.000-08:00

This is the first book solely devoted to single-molecule biochemistry and molecular biology. Authors were selected on the basis of their contribution to this new and exciting field, and were asked to focus more on the biological problems that can be approached using single-molecule techniques rather than on the techniques per se. It is thought that such techniques will eventually dominate the physical characterization of biologically important macromolecules.
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Analytical Biochemistry (3rd Edition)

2009-01-15T11:07:00.000-08:00

Now an established handbook of principles and techniques, this text develops an understanding of the relevance of four fundamental properties of the analyte: shape, polarity, charge and size, to the three key types of analysis: separation, identification and quantification. The third edition of Analytical Biochemistry has now been fully updated in content and format, making it even more accessible to students learning how to select analytical techniques and recognise.
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Bioinformatics for Dummies

2009-01-15T11:06:00.000-08:00

Explore the human genome and analyze DNA—without leaving your desktop! All it takes is the basics of molecular biology and the wealth of information in this friendly guide. You'll discover the online tools and useful tips you need to ask the right questions, analyze sequences, and compare results. It's a plain-English introduction to the field! .

The Science of Laboratory Diagnosis

2009-01-15T11:05:00.000-08:00

This fully revised and updated edition of The Science of Laboratory Diagnosis provides a concise description of all common laboratory tests available in medical practice with notes on their application, the accuracy of each test, the historical background to the adoption of various tests and their effectiveness in diagnosis.medifast weight loss

* Well illustrated, with clear headings, tables, flow charts and pathology slides, most in full colour
* Provides an accessible reference book in which relevant information can be found easily
* Page design facilitates rapid assimilation of principles and key facts
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States of Mind: New Discoveries About How Our Brains Make Us Who We Are

2009-01-15T11:03:00.000-08:00

An all-star lineup of scientists takes you to the front lines of brain research.

Are we born to be shy? Why do we remember some events so clearly and others not at all? Are creativity and depression somehow linked? Do our dreams really have deeper meanings?

Now in paperback, here medifast weight is a wonderfully accessible introduction to the most important recent findings about how our health,lawyers medifast behavior, accutane class actionfeelings, and identities are diet mesothelioma influenced by what goes on inside our brains. In this timely book, eight pioneering researchers offer lively and stimulating discussions on the most exciting discoveries as well as a new way of understanding our emotions, moods, memories, and dreams. Inside, .

Cells, Gels and the Engines of Life

2009-01-13T01:45:00.001-08:00

Pollack's book is extremely insightful, although sometimes controversial. It looks at cell biology from a unique viewpoint. After reading this book, I have re-evaluated many established concepts in cell biology with new understanding and perspective. This is a must read for any serious student or researcher in the field of cell biology. I highly recommend this book. .

The Biochemistry of Cell Signalling

2009-01-13T01:44:00.001-08:00

The Biochemistry of Cell Signalling deals in depth with the principles of cell signalling, concentrating on structure and mechanism. It will serve as a reliable map through the maze of cell signalling pathways and help the reader understand how malfunctions in these pathways can lead to disease. The book is divided into four parts. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. The design of signalling cascades is explained bydescribing central signalling pathways: the Ras-regulated MAPK and PI-3 pathways; the Rho/Rac/Cdc 42 pathway controlling chemotaxis and regulating the cytoskeleton; the G protein coupled receptor cascades in response to sensory and hormonal signals; signalling by TGF-ss in morphogenesis; cytokine signalling that controls haemopoiesis. .

Protein Engineering For Industrial Biotechnology

2009-01-13T01:42:00.000-08:00

Protein engineering has proved to be one of the more fruitful technological approaches in biotechnology, being both very powerful and able to generate valuable intellectual property. This book aims to present examples in which the application of protein engineering has successfully solved problems arising in industrial biotechnology. There is a section on its use to enhance purification of recombinant proteins. The use of protein engineering to modify the activity or the stability of industrial enzymes from lipases to proteases, from carboxypeptidases to glucanases and glucosidases, and from pectin modifying enzymes to enzymes able to degrade recalcitrant compounds is extensively covered. It is shown how areas as diverse as agrofood technology, fine chemistry, detergents, bioremediation and biosensors receive significant contributions from protein and solvent engineering. The application of protein engineering to health care is also covered, from the development of new vaccines to new potential therapeutic proteins. A specific notation is given to protein engineering in the development of target molecules for drug discovery. International in scope, the many contributions are drawn from academia and industry. The text should be of interest to students and researchers in industrial biotechnology as well as to everybody interested in basic research in protein structure, molecular genetics, bio-organic chemistry, biochemistry, agrobiotechnology, pharmaceutical sciences and medicine .

Fundamental Virology 4th edition

2009-01-13T01:41:00.000-08:00

Designed for graduate students and researchers in all biological and biomedical sciences, this volume brings together the basic science chapters from the two-volume Fourth Edition of Fields Virology. These 37 chapters comprise a comprehensive text and reference on the concepts and research
techniques of contemporary virology and the biochemistry, molecular biology, and replication of all viruses. The first part of the book covers basic concepts of general virology and the second part focuses on specific virus families.
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Guide to Publishing a Scientific Paper

2009-01-08T09:30:00.000-08:00

Ann Körner has done a masterful job of presenting all of the important elements, in an order and style that makes sense and engages - and with a lightness and ease that demonstrates just what she describes!!!

Writing up your scientific results and getting them published can be two distinctly different processes. Körner meshes them seamlessly.

As a published scientist, who currently serves as a public information officer for science and medicine, and teaches science writing, I am delighted to have a book that I can recommend on every level to guide writers clearly in this process. .

Dictionary of DNA and Genome Technology

2009-01-08T08:38:00.000-08:00

A one-of-a-kind dictionary giving clear, concise explanations of terms, techniques and tests used in DNA technology today.

* Covers topics relevant to medicine (diagnosis and gene therapy); veterinary science; biotechnology; biochemistry; pharmaceutical science/drug development; molecular biology; microbiology; epidemiology; genomics; environmental science; plant science/agriculture; taxonomy; and forensic science.

Biopharmaceuticals, an Industrial Perspective

2009-01-08T08:37:00.000-08:00

Biopharmaceuticals, an Industrial Perspective provides a unique and up-to-date insight into the biopharmaceutical industry. Largely written by industrial authors, its scope is multidisciplinary.
The book is of particular relevance to scientists and allied professionals already employed in the biopharmaceutical industry, or to those seeking employment
within this industry. Its scope also renders it an ideal reference source for students undertaking advanced undergraduate or postgraduate courses in biotechnology, pharmaceutical science, biochemistry or medicine.

Biochemistry Demystified

2009-01-08T08:36:00.000-08:00

Learn BIOCHEMISTRY without stressing out your brain CELLS

Trying to understand the chemical processes of living organisms but having trouble metabolizing the complex concepts? Here's your lifeline! Biochemistry Demystified helps synthesize your understanding of this important topic.

This fast and easy guide offers:

Simple enough for a beginner, but challenging enough for an advanced student, Biochemistry Demystified is your key to mastering this vital life sciences subject..

Introduction to Nutrition and Metabolism

2009-01-08T08:32:00.000-08:00

The third edition of this leading textbook builds upon the excellent foundation of the previous two editions. It explains and explores the science underlying our current understanding of the interactions between diet and health, and the basis for current dietary goals and recommendations. It also provides a concise and authoritative description of the biochemistry that is essential to an understanding of the functions of nutrients and the importance of diet and nutrition for health and disease. The discussion of metabolic pathways and their regulation is illustrated by clear and simple diagrams, and is linked throughout to nutritional and physiological aspects..

Redox Biochemistry

2009-01-07T08:03:00.000-08:00

Redox Biochemistry provides an excellent text and useful resource for students and practicing researches on redox biochemistry in medical biochemistry, enzyme structure and catalysis, environmental biochemistry, and nutrition. Additionally, it provides a useful resource for practicing researchers in the fields, particularly those in medicine (carcinogenesis, neurology and n

eurodegenerative diseases, cataracts/lens biochemistry, dental studies), immunology, nutrition, environmental, and pharmaceutical sciences

* Richly illustrated, with full color throughout
* Includes contributions from top-notch authors and experts in the field, and is edited by the leader in redox biochemistry, Ruma Banerjee.

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Advanced Techniques in Diagnostic Microbiology

2009-01-07T08:00:00.001-08:00

:

Clinical microbiologists are engaged in the field of diagnostic microbiology to determine whether pathogenic microorganisms are present in clinical specimens collected from patients with suspected infections. If microorganisms are found, these are identified and susceptibility profiles, when indicated, are determined. During the past two decades, technical advances in the field of diagnostic microbiology have made constant and enormous progress in various areas, including bacteriology, mycology, mycobacteriology, parasitology, and virology. The diagnostic capabilities of modern clinical microbiology laboratories have improved rapidly and have expanded greatly due to a technological revolution in molecular aspects of microbiology and immunology. In particular, rapid techniques for nucleic acid amplification and characterization combined with automation and user-friendly software have significantly broadened the diagnostic arsenal for the clinical microbiologist. The conventional diagnostic model for clinical microbiology has been labor-intensive and frequently required days to weeks before test results were available. Moreover, due to the complexity and length of such testing, this service was usually directed at the hospitalized patient population. their unwavering faith and full support, we would never have had the courage to commence this project..

What Scientists Think by: J. Stangroom

2009-01-07T07:58:00.000-08:00

What are leadin g scientists working
on now? What do they think about the working of the brain, climate change, animal experimentation, cancer, and mental illness? Is science progressing or in retreat? Is this century humankind's last?

These are just some of the compelling questions discussed by twelve of world's leading scientists and scientific thinkers in this fascinating book. In engaging and lucid discussion, they clarify many of the complex scientific challenges and dilemmas facing science today. They also explain what drives their interest in science, revealing something of the often-neglected personal side of science.

Nature Magazine 1 January 2009

2009-01-07T07:47:00.000-08:00

Nature Magazine
1 January 2009 To mark in 2009 the International Year of Astronomy and 400 years since Galileo made his first telescope observations, Nature has commissioned a series of special articles and reviews on topics from telescopes to planets, stars, galaxies and cosmology, plus commentary on the state of the field from top experts. Also take a peek into the science article of the future as Nature publishes the first ever PDF with interactive figure.

This week book

2009-01-03T18:29:00.000-08:00

Getting a PhD: An Action Plan to Help You Manage Your Research, Your Supervisor and Your Project

This book provides information that will help rese arch students avoid needless mistakes. It informs and advises you about many of the important facets of postgraduate research, including:
* what it means to conduct research at doctoral level;
* the requirements for independence, contribution to knowledge, originality and suitability for publication;
* planning a research project over a period of time;
* responsible research practice;
* criteria used in the examination of a PhD.

Antisense and Ribozyme Methodology: Laboratory Companion

Antisense and ribozymes have a relatively short yet successful history as research tools in gene expression studies, and thus are considered as having high potential reagents in treating viral infections and cancer. This laboratory companion provides detailed information on the potential, advantages and limitations of this methodology. It critically discusses potential pitfalls, presents strategies for choosing targets and delivery systems, so as to allow the selection of the optimum methodology for achieving fast and reliable experimental success with any human or other biological system. For researchers, technicians and advanced graduates in experimental medicine, molecular and cell biology.

Biosimulation in Drug Development

This first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms. Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. A further section is devoted to simulating networks and populations, and the whole is rounded off by a look at the potential for biosimulation in industrial drug development and for regulatory decisions. Part of the authors are members of the BioSim Network of Excellence that encompasses more than 40 academic institutions, pharmaceutical companies and regulatory authorities dealing with drug development; other contributors come from industry, resulting in a cross-disciplinary expert reference

RNA Trafficking and Nuclear Structure Dynamics

Over the last few years remarkable progress has been accomplished with respect to our understanding of nuclear structure and trafficking. This volume concentrates on aspects that involve or are of relevance to RNA and RNPs. Topics include fundamental advances and current problems in the structural organization of different subnuclear compartments: chromatin, nucleolus and perinucleolar compartment, Cajal bodies and gems, speckles containing splicing factors, as well as the PML bodies characteristic of ProMyelocytic Leukemia. It also describes recent progress in the dynamic aspects of RNA trafficking and in the latest technologies for live cell imaging of mRNA. The major general message of this volume is that nuclear structure is much more dynamic than previously anticipated.

Medical Statistics at a Glance

Medical Statistics at a Glance provides a concise and accessible introduction and revision aid for undergraduate medical students and anyone wanting a straightforward introduction to this complex subject. Following the familiar, easy-to-use at a Glance format, each topic is presented as a double-page spread with key facts accompanied by clear, informative tables, formulae and graphs. This new edition of Medical Statistics at a Glance: * Contains a second colour throughout to enhance the visual appeal, making the subject even easier to understand * Features worked examples on each topic, with emphasis on computer analysis of data rather than hand calculations * Includes new topics on Rates and Poisson regression, Generalised linear models, Explanatory variables in statistical models and Regression models for clustered data. * Has an accompanying website http://www.medstatsaag.com/containing supplementary material including multiple choice questions (MCQs) with annotated answers for self-assessment

Books

2008-12-18T02:43:00.000-08:00

Schaum's Outline of Immunology

Based on material from 400-600 level Immunology courses, this concise and thorough review of modern concepts in molecular, cellular, and systemic immunology contains over two hundred detailed problems with step-by-step solutions. Taking a problem-solving approach, Schaum's Outline of Immunology is an excellent supplement to any systematic textbook of modern immunology, focusing on the basic tenets of immunology as applied to the dynamics of immune responses and their outcomes, and is perfect for pre-med students who need help in their required immunology courses, as well as for medical and veterinary students who want to update their knowledge.

Microbiological Applications:

The classic resource for undergraduate microbiologz laboratory courses just keeps getting better. The self-contained, clearly illustrated exercises and four-color format make Benson's Microbiological Applications: A Laboratory Manual in General Microbiology the ideal lab manual. Appropriate for either a majors or non-majors lab course, Benson assumes no prior organic chemistry course has been taken.

Thinking about Biology

Intended for biology students, this philosophical commentary on biology makes science students' studies more interesting by offering an easy way of studying the philosophy of science, as well as engaging in debates about the social and political implications of biology. It is a unique biology textbook because it adopts an explicitly philosophical approach.

Drug Discovery and Evaluation:

Safety and Pharmacokinetic Assays

Safety aspects have become an outstanding issue in the process of drug discovery and development. Until 15 years ago, drug discovery and evaluation was a sequential process starting with the selection of the most active compound from a series of newly synthesized compounds by means of special pharmacological assays. Safety aspects were addressed by pharmacological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the new compound. These tests were followed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable half-life time and at oral activity. Safety aspects relied mostly on toxicity studies, which however gave information on changes of organ structure rather than on organ function.

In Situ Hybridization: Laboratory Companion

In situ hybridization is a proven, powerful technique with applications in chromosome and genome analysis, as well as gene expression. Covering a carefully selected range of techniques with immediate and general applications in research and clinical diagnosis, the book starts with genome and DNA mapping, continues through gene expression localization in wholemount and tissue sections, and on to ultrastructural levels. The step-by-step protocols used reflect research in these areas and are all reproducible. .

Books

2008-12-15T06:53:00.001-08:00

The Unwritten Rules of PhD Research

This book looks at things the other books don’t tell you about doing a PhD - what it’s really like and how to come through it with a happy ending! It covers all the things you wish someone had told you before you started:

What a PhD is really about, and how to do one well
The "unwritten rules" of research and of academic writing
What your supervisor actually means by terms like "good referencing" and "clean research question"
How to write like a skilled researcher
How academic careers really work

An ideal resource if someone you care about (including yourself!) is undergoing or considering a PhD. This book turns lost, clueless students back into people who know what they are doing, and who can enjoy life again.

Potassium Channels

Due to the importance of potassium channels in cellular function, researchers have been challenged to develop tools and experimental procedures to probe the function and identify chemicals that modulate the behaviour of this super-family of ion channels. In Potassium Channels: Methods and Protocols, experts in the field present a range of experimental approaches that have been developed to investigate potassium channel structure, function, pharmacology, cell biology, gene expression, and their role in disease. Many of these techniques study potassium channels as cellular proteins as well as the resultant membrane biophysics. Written in the highly successful Methods in Molecular Biology™ series format, the chapters contain brief introductions to the subject, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and a Notes section, which highlights tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Potassium Channels: Methods and Protocols provides a wide range of approaches in order to aid current research projects and inspire new investigations.

BASIC CONCEPTS IN BIOCHEMISTRY

Do you find biochemistry daunting? If so, this time-saving guide offers all the help you need. Compact, yet comprehensive, the second edition of BASIC CONCEPTS IN BIOCHEMISTRY breaks down the complexities of biochemistry into jargon-free, easy-to-remember steps that show you how biochemistry works.And unline reviews that emphasize memorization of facts, this book helps you master the topics that students find most difficult, building your understanding with explanations in everyday language. You'll comprehend the material and feel more comfortable applying it. Along with enhanced figures, the new edition contains two new chapters - one that outlines the concepts of membranes and membrane.

MicroBiology In Action

Microbes play an important role in our everyday lives. As agents of infectious disease, they cause untold human misery, yet their beneficial activities are manifold, ranging from the natural cycling of chemical elements to the production of food. In this introductory text, the authors provide a clear and accessible account of the interactions among microbes, their environments, and other organisms, citing examples of both beneficial and detrimental activities. The book begins by considering positive activities, focusing on environmental microbiology and manufacturing, and then moves on to consider some of the more adverse aspects of microbes, particularly the myriad diseases to which we are susceptible and the treatments currently in use. Microbiology in Action will prove to be a valuable text for those studying microbiology.
Guide to Biotechonolgy

The biotechnology industry originated in the 1970s, based largely on a new recombinant DNA technique whose details were published in 1973 by Stanley Cohen of Stanford University and Herbert Boyer of the University of California, San Francisco. Recombinant DNA is a method of making proteins—such as human insulin and other therapies—in cultured cells under controlled manufacturing conditions. Boyer went on to co-found Genentech, which today is biotechnology’s largest company by market capitalization.

Mastering Your PhD

2008-12-13T00:38:00.000-08:00

Survival and Success in the Doctoral Years and Beyond

"Mastering your PhD" helps guide PhD students through their graduate student days. Filled with practical advice on getting started, communicating with your supervisor, staying the course, and planning for the future, this book is a handy guide for graduate students who need that extra bit of help getting started and making it through. Every year, thousands of students around the world embark on the long and difficult journey toward a PhD. Some of these students will make it through their program with flying colors. Others will experience difficulty getting to the end: some will sink and some will manage to swim – barely. The doctoral years can be daunting. While mainly directed to PhD students in the sciences, the book's scope is broad enough to encompass the obstacles and hurdles that almost all PhD students face at some point in their doctoral training. Who should read this book? Students of the physical and life sciences, computer science, math, and medicine thinking about entering a PhD program, doctoral students at the beginning of their research and any graduate student who is feeling frustrated and stuck. It’s never too early or too late!

Science

2008-12-13T00:37:00.001-08:00

Medical Statistics

2008-12-13T00:36:00.000-08:00

A Guide to Data Analysis and Critical Appraisal

Holistic approach to understanding medical statistics This hands-on guide is much more than a basic medical statistics introduction. It equips you with the statistical tools required for evidence-based clinical research. Each chapter provides a clear step-by-step guide to each statistical test with practical instructions on how to generate and interpret the numbers, and present the results as scientific tables or graphs. Showing you how to: * analyse data with the help of data set examples (Click here to download datasets) * select the correct statistics and report results for publication or presentation * understand and critically appraise results reported in the literature Each statistical test is linked to the research question and the type of study design used. There are also checklists for critically appraising the literature and web links to useful internet sites. Clear and concise explanations, combined with plenty of examples and tabulated explanations are based on the authors’ popular medi

cal statistics courses. Critical appraisal guidelines at the end of each chapter help the reader evaluate the statistical data in their particular context s.

Essentials of Clinical Research

2008-12-13T00:35:00.001-08:00

This book is designed to provide the “student” interested in clinical research a foundation upon which to build more advanced study. The book focuses on clinical trials, in contrast to the many excellent textbooks that address epidemiological research. With the recent interest in patient oriented research, this book should provide a knowledge base that is not necessarily covered in other texts. Chapters discussing the FDA’s role in clinical research, Data Safety and Monitoring Boards, Postmarketing studies, the use of placebo controls, and a focus on clinical trials illustrates this point. In addition, new types of clinical research are evolving, and as such, this book discusses genetic, pharmacoepidemiologic, and implementation research. Finally, chapters on tips on how to write a grant, the mentoring process, and how to present ones research results are unique to this book.

Stem Cell Research and Therapeutics

2008-12-13T00:33:00.000-08:00

This book is an updated reference for one of the most exciting fields of biomedical research- Stem Cell Research and its therapeutic applications. Stem cell research holds great promise for the treatment of many human diseases that currently lack effective therapies. The set of chapters in this book provide insights into both basic stem cell biology and clinical applications of stem cell-based cell replacement therapies for a variety of human diseases, including cardiovascular diseases, neurological disorders, and liver degeneration. It also covers novel technologies for the culture and differentiation of both human embryonic stem cells and adult tissue stem cells. This book summarizes our current state of knowledge in stem cell research and integrates basic stem cell biology with regenerative medicine in an overall context. It is an essential reference for students, research fellows, academic and industrial scientists, and clinicians.

How to Research

2008-12-07T15:18:00.001-08:00

This book helps readers to learn techniques to find the information they need. This revised third edition delivers invaluable guidance on how to collect data, write proposals, and make presentations. Offering you step-by-step techniques for the most efficient and focused research in school or work projects, "How to Research" includes hands-on exercises that build up skills and strengthen research techniques useful for any project, in any field.

Trends in Innate Immunity

2008-12-07T15:16:00.000-08:00

The last decade has witnessed the delineation of innate immunity a new area which has revolutionized our understanding of host-parasite interactions and their impact on defense mechanisms in infectious and noninfectious diseases. This volume of the book series 'Contributions to Microbiology' provides an update of the current knowledge of this expanding field of research and highlights some of its most important aspects. In eleven state-of-the-art articles, eminent international experts in the field address topics such as the innate immune system in mammals and insects, microbial protein ligands, antimicrobial peptides, complement, antibacterial chemokines, the role of neutrophils and monocytes, oxidative innate immune defenses and the effect of aging on innate immunity. The book will be a valuable resource for microbiologists, immunologists, students, scientists of other related disciplines, and clinicians with an interest in infectious or immunological diseases.

Signaling by Toll-Like Receptors

2008-12-07T15:14:00.000-08:00

The recent discovery of an ancient family of toll-like receptors (TLRs) in the immune system has substantially enhanced the potential for a variety of therapies, for both failing immune systems, which leaves the body open to infection or over-active ones, which can lead to chronic inflammation. Signaling by Toll-Like Receptors provides a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors, as well as the high promise for uncovering effective pharmaceutica

Toxicogenomics: A Powerful Tool for Toxicity Assessment

2008-12-07T15:13:00.001-08:00

Toxicogenomics: A Powerful Tool For Toxicity Testing provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology.

Making the Right Moves

2008-12-05T05:31:00.001-08:00

A Practical Guide to Scientifıc Management for Postdocs and New Faculty

Beginning scientists face a variety of challenges in launching their careers. The publications and links on this Web site can help new investigators "make the right moves" and assist those who take on the important task of providing early-career researchers with scientific management training.

Science

2008-12-05T05:29:00.000-08:00

Heavy pollution blankets Tiananmen Square, Beijing, on 27 December 2007. Chinese authorities are taking drastic measures to improve the city's air quality for the Olympics. Bad air is just one of many environmental challenges China is facing.

China's Environmental Challenges

Three Gorges Dam: Into the Unknown
A marvel of engineering, the Three Gorges Dam will start operating at full capacity later this year. Already under way is an epic experiment on how a dam impacts the environment.

Fears Over Western Water Crisis
Dramatic reductions in water flow in the Tarim River, the lifeblood of Xinjiang Province, mean provincial authorities must act fast to conserve water and find alternative water sources.

Dendritic Cells in Clinics

2008-12-05T05:28:00.000-08:00

Great advances have taken place in basic research and the clinical usefulness of dendritic cells (DCs). It has now been clearly established, for instance, that these cells play a crucial role in immune responses against infectious diseases and cancers. Antigen-presenting DCs are widely distributed in the body and regulate both immunity and immune tolerance. Experimental studies have provided important insights into DCs and how they can be used for treating animal models of various diseases that occur in humans. The role of these cells in pathogenesis and the treatment of human diseases is elaborately set forth in this valuable book. Researchers in the field are optimistic that DCs, already in use for treating patients with cancers, soon can be used therapeutically for patients with chronic infections, autoimmune diseases, and allergic manifestations. This volume provides a working definition of DCs and also explains the phenotypes and functions of DCs so that these can be readily understood not only by clinicians but by immunologists, researchers, and students as well.

Molecular Genetics and the Human Personality

2008-12-05T05:26:00.000-08:00

For students of psychopathology and others bold enough to hold in abeyance their understandable misgivings about the conjunction of “molecular genetics” and “human personality,” this work offers an authoritative and up-to-date introduction to the molecular genetics of human personality. The book, with its wealth of facts, conjectures, hopes, and misgivings, begins with a preface by world-renowned researcher and author Irving Gottesman.

Biostatistics and Microbiology

2008-11-28T09:59:00.000-08:00

This “nuts and bolts” book provides a condensation of biostatistical methods that applied microbiology researchers need to perform data analyses. Based on the author’s more than two decades of applied research and teaching experience, it is presented in a straight-forward manner, applicable by practicing microbiologists with minimal backgrounds in mathematics. All methods rely only on the use of a basic hand-held calculator. The overriding goal of this book is to ground one’s microbiological expertise and experience in one’s research pursuits, using biostatistics not as a black box, but as a tool. The book begins with a broad discussion of the experimental process, leading to one-sample, two-sample, and multi-sample comparisons. Each regression analysis will be presented, as well as an example. Nonparametric methods will be discussed, as well as when they should be applied. Finally, special topics of statistics in microbiology (i.e., viral, plant, animal, human, food, industrial and microbial microbiology) will be presented.

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Innovations in Chemical Biology

2008-11-28T09:56:00.000-08:00

The growing role of chemistry, combined with the contribution of chemical and pharmaceutical industries to the science of mankind, are continuously advancing. The system for training researchers in the various areas of chemistry has maintained a largely traditional and single disciplinary focus, although many investigators have broadened their selection of research techniques to encompass organized and integrated programs. As a multidisciplinary, Chemical Biology is one of the fastest expanding areas of science during this century. The interdisciplinary study of molecules in living systems at a health science campus aids the integration of the traditional disciplines of chemistry and biology. This is achieved through understanding the molecular mechanisms of biological processes, which provides the opportunity to manipulate them in a defined and predictable way. Looking forward to the next century, we will witness many more remarkable achievements within Chemistry with its application to different fields, resulting in countless benefits to human health and standards of living.

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The Physical Foundation of Protein Architecture

2008-11-28T09:53:00.000-08:00

A protein requires its own three-dimensional structure for its biological activity. If a chemical agent is added, the biological activity is lost, and the three-dimensional structure is destroyed to become a random coil state. But when the chemical agent is removed, the biological activity is recovered, implying that the random coil state turns back into the original complex structure spontaneously. This is an astonishing event. "The Physical Foundation of Protein Architecture" is intended to solve this mystery from the physicochemical basis by elucidating the mechanism of various processes in protein folding. The main features of protein folding are shown to be described by the island model with long range hydrophobic interaction which is capable of finding the specific residue, and the lampshade criterion for disulfide bonding. Various proteins with known structure are refolded, with the purpose of uncovering the mechanism of protein folding. In addition, ab initio method for predicting protein structure from its amino acid sequence is proposed.

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HIV Protocols: Second Edition

2008-11-28T09:46:00.000-08:00

Major advances in HIV treatment, many areas require more study, in order to create efficacious, potent antiretrovirals that can suppress viral load completely and durably without toxic side effects, to define unknown drug targets and fine-tune known targets, and to better understand the interplay between viral and host factors. In "HIV Protocols, Second Edition", expert researchers provide clear, state-of-the-art methods for the study of HIV. Directed toward three specific goals, this text aims to document up-to-date protocols for select aspects of HIV biology, to bring together both virological and immunological approaches in a single, convenient volume, and to present a comprehensive account of a range of techniques not available in any existing HIV protocol book. As a volume in the highly successful Methods in Molecular Biology™ series, the chapters include brief introductions to the subject, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections containing priceless tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, "HIV Protocols, Second Edition" is an ideal guide to the wide array of techniques used in fundamental or applied research into the biology and pathogenesis of HIV-1.

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Science

2008-11-26T16:28:00.001-08:00

Cover
A mosaic of visible to near-infrared images of the surface of Mercury, obtained by the MESSENGER spacecraft on 14 January 2008. The circular feature in the upper right is the Caloris impact basin, 1500 kilometers in diameter.

Scientific Writing: Easy When You Know How

2008-11-23T11:44:00.000-08:00

This comprehensive and practical book covers the basics of grammar as well as the broad brush issues such as writing a grant application and selling to your potential audience. The clear explanations are expanded and lightened with helpful examples and telling quotes from the giants of good writing. These experienced writers and teachers make scientific writing enjoyable.
Description: This is a very well written book on scientific writing that is easy to read and follow. The format of boxed tables presents the information concisely.
Purpose: The purpose is to make scientists better writers. Writing well is a crucial component of scientific success, one that is often overlooked by formal scientific training. With scientific data generated worldwide, having a book that summarizes the standards of writing in English is very helpful. The authors have done an excellent job in meeting their objectives.

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The Application of Biotechnology to Industrial Sustainability

2008-11-23T11:43:00.001-08:00

In more and more industrial sectors, companies are becoming aware of the importance of sustainable development and of the great potential of biotechnology. Biotechnology can help improve the environmental friendliness of industrial activities and lower both capital expenditure and operating costs. It can also help reduce raw material and energy inputs and waste. This volume brings together for the first time a broad collection of case studies on biotechnology applications in industrial processes and subjected them to detailed analysis in order to tease out essential lessons for industrial managers and for government policy makers. It will encourage the former and provide the latter with basic materials for programme development

Viruses vs. Superbugs

2008-11-23T11:41:00.000-08:00

Pharmacokinetics and Metabolism in Drug Design

2008-11-23T11:34:00.000-08:00

In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs.While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.

Stem Cell Research and Cloning

2008-11-14T11:56:00.000-08:00

The debates presented in Point/Counterpoint are among the most interesting and controversial in contemporary American society,but studying them is more than an academic activity.They affect every citizen; they are the issues that today’s leaders debate and tomorrow’s will decide. The reader may one day play a central role in resolving them. Why study both sides of the debate? It’s possible that the reader will not yet have formed any opinion at all on the subject of this volume but this is unlikely. It is more likely that the reader will already hold an opinion, probably a strong one,and very probably one formed without full exposure to the arguments of the other side. It is rare to hear an argument presented in a balanced way, and it is easy to form an opinion on too little information; these books will help to fill in the informational gaps that can never be avoided. More important, though, is the practical function of the series: Skillful argumentation requires a thorough knowledge of bothsides though there are seldom only two, and only by knowing what an opponent is likely to assert can one form an articulate response.

Cell Fusion: Overviews and Methods

2008-11-14T11:51:00.000-08:00

Exciting work in the past decade has revealed commonalities and differences among individual cell fusion events. In Cell Fusion: Overviews and Methods, a team of leading experts provide a collection of overviews that outline our current understanding of cell fusion and methods that present classic and state-of-the-art experimental approaches in a variety of systems. Divided into two convenient parts, the volume begins with nine overviews which describe different cell fusion events in models from yeast to mammals, and it continues with thirteen chapters illustrating commonly used methods to assay cell fusion in particular systems. As a part of the highly successful Methods in Molecular Biology™ series, these methods chapters compile step-by-step, readily reproducible protocols with lists of the necessary materials and reagents, along with tips on troubleshooting and avoiding known pitfalls. Cutting-edge and user-friendly, Cell Fusion: Overviews and Methods serves as a comprehensive resource for anyone, expert or novice, interested in the fascinating biological process of cell fusion.

DNA Methylation: Methods and Protocols

2008-11-14T11:50:00.001-08:00

Over the past few years, DNA methylation technologies and our knowledge of DNA methylation patterns have been advancing at a breathtaking pace. Due to this fact, DNA Methylation: Methods and Protocols, Second Edition completely revises, updates, and expands upon the popular first edition with the most current novel techniques, easier to use and more refined by the tested experience of leading experts. This revision reflects contemporary study of the subject: the analysis of gene-specific DNA methylation patterns has been complemented by genome-wide approaches, and epigenomics takes a central place. Written in the highly successful Methods in Molecular Biology™ series format, the chapters in this volume present brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, DNA Methylation: Methods and Protocols, Second Edition is the perfect resource for scientists who wish to further our understanding of the molecular processes that determine the genomic DNA methylation landscape and for those who aim to identify and implement DNA methylation-based biomarkers for clinical and diagnostic applications.

Mass Spectrometry: A Textbook

2008-11-14T11:06:00.000-08:00

This book is tailored for students and professionals as well as novices from other fields to mass spectrometry. It will guide them from the basics to the successful application of mass spectrometry in their daily research. Starting from the very principles of gas-phase ion chemistry and isotopic properties, it leads through the design of mass analyzers and ionization methods in use to mass spectral interpretation and coupling techniques. Step by step the readers will learn how mass spectrometry works and what it can do as a powerful tool in their hands. The book comprises a balanced mixture of practice-oriented information and theoretical background. The clear layout, a wealth of high-quality figures and a database of exercises and solutions, accessible via the publisher’s web site, support teaching and learning.

Molecular Biomethods Handbook

2008-11-10T13:34:00.000-08:00

Recent advances in the biosciences have led to a range of powerful new technologies, particularly nucleic acid, protein and cell-based methodologies. The most recent insights have come to affect how scientists investigate and define cellular processes at the molecular level. Molecular Biomethods Handbook, 2nd Edition expands upon the techniques included in the first edition, providing theory, outlines of practical procedures, and applications for a range of techniques. Part A of the book describes nucleic acid methods, such as gene expression profiling, microarray analysis and quantitative PCR. In Part B, protein and cell-based methods are outlined, in subjects ranging from protein engineering to high throughput screening. Written by a well-established panel of research scientists, Molecular Biomethods Handbook, 2nd Edition provides an up to date collection of methods used regularly in the authors’ own research programs. This book will prove to be an invaluable reference for those engaged in or entering the field of molecular biology, and will provide the necessary background for those interested in setting up and using the latest molecular techniques.

Meat Biotechnology

2008-11-10T13:26:00.000-08:00

Meat and meat products constitute one of the most important foods in western societies. However, the area of meat biotechnology is not as comprehensively covered as other areas of food biotechnology. Missing from this area are the recent developments for better sensory and nutritional quality as well as improved safety. The main goal of this book is to provide the reader with the recent developments in biotechnology and their applications in the meat processing chain. To achieve this goal, the book is divided into four parts. The first part deals with the use of modern biotechnology applied to farm animals. The second part focuses on the recent biotechnological developments in starter cultures for better meat fermentation. The third part discusses current approaches to improve the quality and nutritional properties of meats. The final part presents the latest advances in protection against foodborne pathogens, and other recent trends in the field. Written by distinguished international contributors, this book brings together the advances in such varied and different biotechnological topics.

Nature Cell Biology Sep Volume 10

2008-11-05T08:09:00.000-08:00

What Can You Do with a Major in Biology?

2008-11-04T10:14:00.001-08:00

The complete guide to making the most of a biology degree

One of the top ten college majors in America today, biology can lead to a spectrum of careers?from jobs in the ever-expanding health care industry to options in oceanography, food chemistry, and botany. Students considering a biology major and grads of any age seeking new directions will find What Can You Do with a Major in Biology? the most thorough, easy-to-use resource available?with real profiles, outlines of career paths, salary levels, and much more.

Series author Jennifer A. Horowitz (New York, NY) holds degrees from Columbia University?s Teachers College and from Barnard College in writing. She has worked in New York City schools, with educational publishers, and as an advisor to parents of gifted children.

Gene and Cell Therapy

2008-11-04T04:57:00.000-08:00

The latest edition of Gene and Cell Therapy provides comprehensive coverage of all aspects of the tools and state-of-the-art technologies that are currently available in this field. Written by international leaders, this third edition features 12 additional chapters that address such new topics as gene and cell therapies for diabetes and cardiovascular disease, relevant nanotechnologies, siRNA therapeutics, dendrimers, clinical trials, human embryonic stem cell research, tissue engineering, and novel polymers. All chapters in the text have been substantially updated and revised to reflect the latest information available in the field.

Biochemistry For Dummies

2008-10-30T06:43:00.001-07:00

Covers proteins, carbohydrates, and genetics Grasp biochem basics, apply the science, and ace your exams Are you baffled by biochemistry? This unintimidating guide makes it easy to understand, explaining all the topics and practical applications in plain English. From cell ultrastructure and carbohydrates to amino acids, proteins, and supramolecular structure, you'll identify biochemical structures and reactions, improve your grades, and get ready to tackle your tests. John Moore, EdD, is the author of Chemistry For Dummies and an editor for The Journal of Chemical Education. Richard Langley, PhD, is a grader for the Free Response portion of the AP Chemistry Exam. Discover how to: Master biochemistry basics Work through biochem problems Prepare for standardized tests Apply biochem in everyday life Explore a career in the field

Viral Therapy of Cancer

2008-10-30T06:39:00.001-07:00

Viral agents have been developed that are harmless to normal tissues but selectively able to kill cancer cells. These agents have been endowed with additional selectivity and potency through genetic manipulation. Increasingly these viruses are undergoing evaluation in clinical trials, both as single agents and in combination with standard chemotherapy and radiotherapy. This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient’s bedside, they give an up-to-date and realistic evaluation of a therapy’s potential utility for the cancer patient. * Presents state of the art knowledge on how viruses can be, and have been, used in novel therapeutic approaches for the treatment of cancer * Describes the use of viruses as oncolytic agents, killing cells directly * Editors are experts in the field, with experience of both laboratory and clinical research Viral Therapy of Cancer is essential reading for both basic scientists and clinicians with an interest in viral therapy and gene therapy

Digestion and Nutrition

2008-10-30T06:35:00.000-07:00

Title: Digestion and Nutrition

Author(s): Robert J. Sullivan

Series: Your Body: How It Works

Publisher: Chelsea House Publications

ISBN: 079107739X

Publication: 2004

Pages: 118

Description: n/a s.

Autoantibodies

2008-10-30T06:30:00.000-07:00

Autoimmune diseases are characterized by the occurrence of antibodies reacting with self constituents of the body. This exciting new reference is an exhaustive review of the main autoantibodies identified up to now, with particular emphasis on those autoantibodies that display a clinical value. Each chapter is focussed on a single family of autoantibodies by reviewing their historical notes, definition, origin and source(s) of the antigen(s) recognized, genetic associations, pathogenic mechanisms that are mediated, method(s) of detection and clinical utility (disease prevalence/association, diagnostic value, sensitivity and specificity, prognostic value). An ideal reference for anyone involved in the field of autoimmune diseases. * Incudes and exhaustive list of autoantibodies not covered by other publications * Short reviews can easyily be checked for quick reference information * Both basic and clinical aspects are covered

Bioinorganic Electrochemistry

2008-10-13T01:20:00.000-07:00

Interfacial electrochemistry of redox metalloproteins and DNA-based molecules is presently moving towards new levels of structural and functional resolution. This is the result of powerful interdisciplinary efforts. Underlying fundamentals of biological electron and proton transfer is increasingly well understood although with outstanding unresolved issues. Comprehensive bioelectrochemical studies have mapped the working environments for bioelectrochemical electron transfer, supported by the availability of mutant proteins and other powerful biotechnology. Introduction of surface spectroscopy, the scanning probe microscopies, and other solid state and surface physics methodology has finally offered exciting new fundamental and technological openings in interfacial bioelectrochemistry of both redox proteins and DNA-based molecules. Inorganic Bioelectrochemistry provides a thorough and didactic overview of state-of-the-art bioelectrochemistry with prospects for forthcoming development. The book is organized in eight chapters written by leading international experts and covers crucial relevant topics such as electron and proton transfer in metalloprotein systems, electrochemistry and electrocatalysis of redox enzymes, and electrochemistry of DNA-based molecules. A wide variety of readers will find this volume of great interest. These include final year undergraduate and postgraduate students, university lecturers in inorganic and physical chemistry as well as the biochemical and biological sciences, and research staff in medical and biotechnological companies, catalysis research, and other industries.

Genetics of Developmental Disabilities

2008-10-13T01:12:00.000-07:00

This authoritative reference provides expert discussions of the development, classification, diagnosis, and treatment of developmental disabilities-emphasizing research advances in genetics, molecular and cytogenetic testing, and molecular biological technologies for an improved understanding of the causes and factors that may contribute to these disorders.

RNAi

2008-10-13T01:11:00.000-07:00

Title: RNAi: RNAi (Advanced Methods)

Author(s): Mart Latterich

Series: n/a

Publisher: Taylor & Francis

ISBN: 0415409500

Publication: 2007

Pages: 138.

Medical Biotechnology

2008-10-13T01:06:00.000-07:00

Title: Medical Biotechnology: Achievement, Prospects And Perceptions

Author(s):Albert Sasson

Series: n/a

Publisher: United Nations University Press

ISBN: 9280811142

Publication: 2006

Pages: 168

Description: n/a s.

2 October 2008 - Nature Issue

2008-10-08T05:01:00.001-07:00

Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

Nucleic Acids in Innate Immunity

2008-10-07T01:06:00.000-07:00

Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation of this previously unexploited branch of the immune system. Drawing on the research of leading experts, Nucleic Acids in Innate Immunity provides insight in this new area of immunology. The book begins by explaining the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLR), and RIG-I-like receptors (RLR). RNA are recognized by the innate immune system. Contributions review recent advances to understand innate immune recognition of nucleic acids and describe the resulting immune modulation. Providing a comprehensive review of nucleic acid recognition and regulation by the innate immune system, this seminal work reveals new directions for future research in immune modulation.

Bioprocessing-Biotechnology

2008-10-07T01:04:00.001-07:00

Bioprocessing: an exciting new engineering discipline. It combines the development and optimization of biotechnological processes with effective strategies to recover and purify the desired products. Safety as well as cost play an important role here. This volume covers the immensely differentiated spectrum of techniques and operations of bioprocessing, presented by the most competent experts in the field. An overview of upstream and downstream processing is given, fermentation and cell culture processes and the design of microbial fermenters are presented. A closing group of chapters is dedicated to issues of process validation, measurement, and regulation. Topics included are: Industrial Cell Cultures/ Pharmaceutical Proteins/ Bioreactors/ Media and Air Sterilization/ Oxygen Transfer/ Scale Implications/ Fermentation Data Analysis/ Cell and Debris Removal/ Protein Purification/ Electrokinetic Separations/ Final Recovery Steps/ Process Validations.

Phagocytosis of Bacteria and Bacterial Pathogenicity

2008-10-07T00:58:00.000-07:00

This book provides up-to-date information on the crucial interaction of pathogenic bacteria and professional phagocytes, the host cells whose purpose is to ingest, kill, and digest bacteria in defense against infection. The introductory chapters focus on the receptors used by professional phagocytes to recognize and phagocytose bacteria, and the signal transduction events that are essential for phagocytosis of bacteria. Subsequent chapters discuss specific bacterial pathogens and the strategies they use in confronting professional phagocytes. Examples include Helicobacter pylori, Streptococcus pneumoniae, and Yersinae, each of which uses distinct mechanisms to avoid being phagocytosed and killed. Contrasting examples include Listeria monocytogenes and Mycobacterium tuberculosis, which survive and replicate intracellularly, and actually cooperate with phagocytes to promote their entry into these cells. Together, the contributions in this book provide an outstanding review of current knowledge regarding the mechanisms of phagocytosis and how specific pathogenic bacteria avoid or exploit these mechanisms.s.

Genetic Engineering

2008-10-07T00:55:00.001-07:00

Title: Genetic Engineering

Author(s):Harry LeVine

Series: Contemporary World Issues

Publisher: ABC-CLIO

ISBN: 1851098607

Publication: 2006

Pages: 313

Instant Notes in Biochemistry

2008-10-05T06:09:00.000-07:00

Instant Notes in Biochemistry, 2/e provides an easy access to the fundamentals in this field. The book is a major update on the very successful first edition with expanded coverage of transcription, RNA processing and protein synthesis and many additional new topics. New illustrations have been added and much of the artwork has been enlarged or redrawn to aid comprehension.

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Introduction to Pharmacology

2008-10-05T06:03:00.000-07:00

The first edition of Introduction to Pharmacology has over recent years become a highly influential text among students wishing to acquire a knowledge of pharmacology without having to refer to the larger, more detailed, traditional pharmacology volumes. This revised and updated second edition contains significant new material to bring the reader up-to-date with the latest practices and principles in pharmacology. Exploring the basic principles in both the therapeutic and toxicological aspects of drug use, the book employs contemporary examples of medication, supplemented with an increased number of accurate and easy-to-interpret figures and diagrams. Additionally, Introduction to Pharmacology presents the important concept of understanding the limitations surrounding the drugs that cure, replace physiological inadequacies, or treat symptoms, and which have led to the system of drug classification. The broad scope of the book also encompasses the role of the FDA, drugs in sport, and the use of animals for drug experimentation.

Structural Proteomics: High-Throughput Methods

2008-10-05T05:55:00.000-07:00

Structural genomics is a newly emerging field that has arisen following the successful footsteps of the major sequencing efforts generally bundled under the heading "genomics". In Structural Proteomics: High Throughput Methods, readers are provided with a current view of all aspects of the 'pipeline' that takes protein targets to structures and how these have been optimized. This volume includes chapters describing in-depth the individual steps in the Structural Genomics pipeline, as well as overviews of individual Structural Genomics initiatives. Topics include Target Selection for structural genomics, Protein structure modeling, High-throughput cloning, Mass Spectrometry modeling. Structural Proteomics: High Throughput Methods, encourages its readers to access further details on the methodologies in on-line resources as well as in cited literature making it an invaluable resource. Most methods in this important book are as amenable to small laboratories as to large consortia, and do not require major investments in facilities. This essential volume provides insight into the diversity of approaches adopted by different laboratories and proves that 'high throughput' is really the defining characteristic.

DNA: Promise and Peril

2008-10-02T03:10:00.001-07:00

The genetic revolution has provided incredibly valuable information about our DNA, information that can be used to benefit and inform--but also to judge, discriminate, and abuse. An essential reference for living in today's world, this book gives the background information critical to understanding how genetics is now affecting our everyday lives. Written in clear, lively language, it gives a comprehensive view of exciting recent discoveries and explores the ethical, legal, and social issues that have arisen with each new development.